What You Need to Know About PAS 91:2013+A1:2017 - The Free Download for Prequalification in Construction
PAS 91:2013+A1:2017 is an updated version more closely aligned with the standard Selection Questionnaire and ESPD. Updating has included amendments to questions about supplier identity and financial information which reflect the approach of Part 1 of the SQ. New tables, for use by public sector purchasers, list the mandatory and discretionary grounds for exclusion set out in the 2015 Public Contracts Regulations with suppliers required to self-declare compliance.
pas 91 2017 free download
The intention appears to be that PAS 91:2013+A1:2017 is used as the standard questionnaire for procurement of works contracts over the relevant thresholds, without the need to mix and match with the standard Selection Questionnaire published by Crown Commercial Service.
At the end of 2017, the BSI published the long-awaited amendment to the PAS 91 Questionnaire. The amendments include minor changes to the text of some questions and the inclusion of new questions covering mandatory reasons for exclusion and legislation relating to the Immigration Act and the Minimum Wage Act.
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The most recent amendment of the PAS 91 questionnaire (PAS 91:2013+A1:2017) saw it aligned with Public Contracts Regulations 2015 and CDM Regulations 2015. It is also closely aligned with both the Standard Selection Questionnaire and the ESPD (European single procurement document) and is commonly used in procuring works contracts, without the need to mix and match with the standard selection questionnaire.
Diverse approaches to mRNA cancer vaccines, including dendritic cell vaccines and various types of directly injectable mRNA, have been employed in numerous cancer clinical trials, with some promising results showing antigen-specific T cell responses and prolonged disease-free survival in some cases.
Injection of naked mRNA in vivo. Naked mRNA has been used successfully for in vivo immunizations, particularly in formats that preferentially target antigen-presenting cells, as in intradermal61,65 and intranodal injections66,67,68. Notably, a recent report showed that repeated intranodal immunizations with naked, unmodified mRNA encoding tumour-associated neoantigens generated robust T cell responses and increased progression-free survival68 (discussed further in Box 2).
Intranasal vaccine administration is a needle-free, noninvasive manner of delivery that enables rapid antigen uptake by DCs. Intranasally delivered mRNA complexed with Stemfect (Stemgent) LNPs resulted in delayed tumour onset and increased survival in prophylactic and therapeutic mouse tumour models using the OVA-expressing E.G7-OVA T lymphoblastic cell line145.
All enzymes and reaction components required for the GMP production of mRNA can be obtained from commercial suppliers as synthesized chemicals or bacterially expressed, animal component-free reagents, thereby avoiding safety concerns surrounding the adventitious agents that plague cell-culture-based vaccine manufacture. All the components, such as plasmid DNA, phage polymerases, capping enzymes and NTPs, are readily available as GMP-grade traceable components; however, some of these are currently available at only limited scale or high cost. As mRNA therapeutics move towards commercialization and the scale of production increases, more economical options may become accessible for GMP source materials.
Once the mRNA is synthesized, it is processed though several purification steps to remove reaction components, including enzymes, free nucleotides, residual DNA and truncated RNA fragments. While LiCl precipitation is routinely used for laboratory-scale preparation, purification at the clinical scale utilizes derivatized microbeads in batch or column formats, which are easier to utilize at large scale156,157. For some mRNA platforms, removal of dsRNA and other contaminants is critical for the potency of the final product, as it is a potent inducer of interferon-dependent translation inhibition. This has been accomplished by reverse-phase FPLC at the laboratory scale158, and scalable aqueous purification approaches are being investigated. After mRNA is purified, it is exchanged into a final storage buffer and sterile-filtered for subsequent filling into vials for clinical use. RNA is susceptible to degradation by both enzymatic and chemical pathways157. Formulation buffers are tested to ensure that they are free of contaminating RNases and may contain buffer components, such as antioxidants and chelators, which minimize the effects of reactive oxygen species and divalent metal ions that lead to mRNA instability159.
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To access this dataset in Earth Engine, please sign up for Earth Engine then return to this page. Cancel Sign up FeatureView new_releases ui.Map.FeatureViewLayer("WCMC/WDPA/current/polygons_FeatureView") open_in_new Sign up for Earth Engine Earth Engine is free to use for research, education, and nonprofit use.
Asset Naming Conventions. WCMC updates the WDPA on amonthly basis. The most recent version is always available asWCMC/WDPA/current/polygons and WCMC/WDPA/current/points. Historicalversions, starting with July 2017, are available in the formatWCMC/WDPA/YYYYMM/polygons and WCMC/WDPA/YYYYMM/points.
eFootball PES 2023 for Android was released in its mobile version on June 1. Since that day, you can download the APK on Uptodown to try all the available game modes. In any case, for months now, you can play it on Xbox or PS5.
The eFootball PES 2023 APK for Android has a size of 2.53 GB, and subsequently, you will need to download some additional data. It is recommended to have a smartphone with at least 5 GB of available storage to fully enjoy the game experience.
This is followed by the king of social media, Facebook. Seven in ten marketers plan to do video marketing on the platform. Having launched video features only as recently as 2017, LinkedIn is a relatively new player as a video marketing platform. But, already, it has surpassed other platforms like Instagram and Twitter to become the third-most-popular social media platform for video marketing. Just under two-thirds (63%) of marketers say they will be using video on LinkedIn.
To further put things into perspective, 56 exabytes (equivalent to one billion gigabytes) of internet video was consumed on a monthly basis in 2017. This figure more than quadrupled to 240 exabytes per month in 2022.
This document contains instructions for downloading the most current fix packs and interim fixes from Fix Central. You can download the IBM Spectrum Protect server and client, IBM Spectrum Protect for SAN, and the Operations Center. The IBM Spectrum Protect for SAN (storage agent) product is packaged with the server.
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An IPCC special report on the impacts of global warming of 1.5 C above pre-industrial levels and related global greenhouse gas emission pathways, in the context of strengthening the global response to the threat of climate change, sustainable development, and efforts to eradicate poverty. The translations of the SPM and other material can be downloaded from this link
The probability of a sea-ice-free Arctic Ocean5 during summer is substantially higher at 2C compared to 1.5C of global warming (medium confidence). Model simulations suggest that at least one sea-ice-free Arctic summer is expected every 10 years for global warming of 2C, with the frequency decreasing to one sea-ice-free Arctic summer every 100 years under 1.5C (medium confidence). An intermediate temperature overshoot will have no long- term consequences for Arctic sea ice coverage, and hysteresis is not expected (high confidence). 3.3.8, 22.214.171.124
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